The Red Devils boss vented his frustration with his side's fixture schedule after Thursday's 1-0 win over Rostov, which saw them scrape through to the last eight.
"I think they don't give an Sh*t about the English teams in Europe".
He said: "We should be the last team to play in the weekend".
"We were just looking at some of the cup fixtures they've had".
"They defend with a block of 10 players and that makes it hard", the Portuguese said. I don't ask for me, but for all the English teams. "We can not even sleep on Sunday morning because we have to wake up at seven o'clock to eat and go to the game".
"Every country, they try to do that little support to the teams in European football, but here it's hard".
The club's assistant manager has stepped in as caretaker after the Spaniard's stormy three-and-a-half year reign was brought to an end with the Teessiders second-bottom of the Premier League and in danger of an immediate return to the Championship.
He's the manager of Manchester United, one of the biggest clubs on the planet, the squad he's got, the players. I think, in England, it's a little bit the same.
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"But Mourinho has launched a passionate defence of Pogba, still only 24, and insists his strong personality means that he "does not give a 's" about his critics.
"We now have to play Middlesbrough at 12 o'clock on Sunday. Why?"
"When I first arrived at Chelsea, I wanted to buy Manchester City's best player (Shaun Wright-Phillips) and I did".
"That gave me energy to score", said the Spaniard, who started and finished the best move of a heavy night for a worn out United as they struggled to overcome the Russian side. "That's obvious", said Mourinho, whose side have played 11 games in just over six weeks.
He was analysed on the side of the pitch before the decision was made to let him sit out the rest of the match, and it seems a smart one as he's already back in selection.
30' CHANCE! Mkhitaryan times his run brilliantly, spots the goalkeeper moving, and looks to flick the ball over him - but it rolls wide. I really enjoyed his work and his company during my two and a half years working with him.
Thursday's win set up a two-legged Europa League quarter-final tie against Anderlecht next month, but also added to the fixture congestion that has left Mourinho deeply unhappy.