The striker, who has scored 24 goals for Spurs this campaign, left White Hart Lane on crutches and with his right foot in a protective boot, leaving Manager Mauricio Pochettino fearing his season might be over.
Kevin Kilbane thinks Tottenham Hotspur will be unsafe opponents in the FA Cup semi-final, after he watched Mauricio Pochettino's side thrash Millwall 6-0 in their quarter-final tie at White Hart Lane.
"He twisted his ankle".
"We will assess tomorrow, and after tomorrow, and see what happens".
"It's hard. We hope it's not a big issue but it looks a similar situation as his previous injury".
"It will be hard for him to play against Southampton on Sunday, but we need to be cautious".
Son scored a hat-trick at White Hart Lane as Spurs thrashed the Lions 6-0, but their victory was marred by abusive songs aimed at the South Korean from the visiting supporters.
Pochettino admitted later to major concerns about Kane, who looks certain to miss England's games against Lithuania and Germany later this month.
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Tottenham did suffer a setback with Harry Kane being forced off with an ankle injury early on, but it didn't effect them as they kept their composure in front of goal and produced a convincing display. We can not cry. We have enough players to replace him and win games.
"It was an important win for us, not just for The FA Cup but for the league as well - it was important to keep our form and keep getting the goals".
"For us it's given us momentum this year - and inspiration - we were 17 games unbeaten before today. We have players enough to try and replace him", Pochettino said.
Meanwhile, disappointed Millwall manager, Neil Harris, said: "We all came today with inspirations of what the FA Cup is all about and what we have achieved in previous rounds".
"We've enjoyed this competition - its' a been a great distraction for us", Harris enthused.
Son can never be sure of a starting spot but he has netted 13 goals this season. "We want people to be dealt with harshly, of course". "It's wrong in football and wrong in society". No, we're talking about Vincent Janssen.
Dominating possession easily, Pochettino's side battered Millwall from start to finish as they cruised to a 16th win from 18 home games this season.